Urine Biomarkers for Renal Function Monitoring in Preterm Infants

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02813109

Enrollment

Registered

2016-06-24

Start date

2016-06-30

Completion date

2017-03-02

Last updated

2017-04-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Premature Infant

Brief summary

The true renal function of preterm infants is difficult to evaluate. Serum creatinine (Cr) levels in infants are unreliable as a detector of renal function in the first few days of life because they may continue to reflect maternal levels. Although few candidates appear to be a useful biomarker for kidney injury, scant reference data on these biomarker in preterm infants exist, and studies have yielded conflicting results. Therefore, we aimed to determine the reliable urinary biomarkers to detect kidney injuries in preterm infants.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

1 Days to 2 Weeks

Healthy volunteers

Yes

Inclusion criteria

* premature infants born before 37 weeks of gestational age

Exclusion criteria

* cardiac or renal anomalies * transferred in 2 days after birth from other hospitals

Design outcomes

Primary

Measure	Time frame
correlation of urinary NGAL (neutrophil-gelatinase-associated lipocalin) with serum creatinine	postnatal 1day

Countries

South Korea

Outcome results