Effects of Total Intravenous Anesthesia With Propofol-remifentanil Versus Inhalational Anesthesia With Sevoflurane on Quality of Recovery in Patients Undergoing Transsphenoidal Surgery for Pituitary Tumor

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02813044

Enrollment

Registered

2016-06-24

Start date

2016-06-16

Completion date

2018-06-15

Last updated

2020-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pituitary Tumor

Keywords

anesthesia, intravenous, neurosurgery, pituitary neoplasm, postoperative period

Brief summary

A number of studies have compared the effects of total intravenous anesthesia(TIVA) versus inhalational anesthesia on perioperative period during transsphenoidal surgery. However, they have limitations especially for the phase of recovery after anesthesia: a fragmentary assessment. Quality of Recovery 40 (QoR-40) questionnaire was multi-dimensionally designed to assess the degree of recovery, specially after anesthesia and surgery. In this study, the investigators aim to compare the quality of recovery after inhalational anesthesia and after TIVA through QoR-40 questionnaire in patients undergoing transsphenoidal surgery for pituitary tumor under general anesthesia.

Interventions

DRUGtotal intravenous anesthesia (TIVA)

In the TIVA group,anesthesia is induced and maintained by effect-site target controlled infusion of propofol and remifentanil.

DRUGinhalation anesthesia group

In the inhalation anesthesia group, anesthesia is induced by pentothal sodium 4-6mg/kg and remifentanil 1 μg/kg, and then maintained with end-tidal sevoflurane concentration of 0.8 to 1 MAC and continuous infusion of remifentanil at 0.1-0.3μg/kg/min.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

OTHER

Masking

DOUBLE (Subject, Investigator)

Eligibility

Sex/Gender

ALL

Age

19 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients over age 19 * Scheduled to undergo transsphenoidal surgery for pituitary tumor * ASA class I and II

Exclusion criteria

* Left ventricular ejection fraction \< 55% * Third-degree atrioventricular block * Second-degree atrioventricular block (P:QRS ratio of 3:1 or higher) * Fever * History of myocardial infarction, stroke or cardiac surgery within the previous 1 year * Severe neurological disease * Use of sedative, opioid or sleep-inducing drugs * Allergic history of any study drug * Pregnancy

Design outcomes

Primary

Measure	Time frame	Description
QoR-40 score	1 day	We compare the QoR-40 scores of two groups 1 day after the operation.

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026