Myocardial Ischemia, Reperfusion Injury
Conditions
Brief summary
This study aims to understand the impact of time-of-the day on human myocardial tolerance to ischemia-reperfusion by exploring atrial myocardium biopsied during cardiac surgery. Patients scheduled for non-urgent cardiac surgery (coronary artery by-pas graft and/or aortic valve replacement) will be assigned to a morning or an afternoon cardiac surgery based on randomization. Myocardial biopsies will be explored in ex vivo conditions mimicking ischemia-reperfusion.
Interventions
PROCEDUREcardiac surgery scheduled in the morning
cardiac surgery scheduled in the morning
PROCEDUREcardiac surgery scheduled in the afternoon
cardiac surgery scheduled in the afternoon
Sponsors
University Hospital, Lille
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patient scheduled for coronary artery bypass graft surgery and/or aortic valve replacement with extra-corporeal circulation * Patient in sinus rhythm at the time of surgery * Patient older than 18 * Patient able to understand the information and consent forms
Exclusion criteria
* Medical history of type 2 diabetes, atrial fibrillation or use of class III anti-arhythmic drug * left ventricle ejection fraction \< 40% * Pregnancy * Patient in emergency condition
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| ischemia reperfusion injury in ex vivo conditions | the day of the myocardial biopsy | measurement of hs troponin T released by the myocardium samples in the superfusion solution after ex vivo conditions mimicking ischemia-reperfusion |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORDavid Montaigne, MD, PhD
Lille University Hospital
Outcome results
None listed