Chronic Heart Failure
Conditions
Keywords
Adipokines, Chronic Heart Failure, Prognosis
Brief summary
The purpose of this study is to determine whether expressions of adipokines can provide prognostic information concerning patients with chronic heart failure.
Interventions
None listed
Sponsors
Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
12 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients who are giving open chest surgical treatment with a history of chronic heart failure (NYHA II \ IV) more than 6 months. * Patients from whom informed consent has been properly obtained in writing prior to start of the trial.
Exclusion criteria
* Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases,or any other malignancy. * Patients with a history of cardiomyopathy. * Patients with Chronic arrhythmia. * Pregnant women * Severe hepatic dysfunction or End-stage renal failure. * Uncontrolled hypertension.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All-cause mortality | Change from Baseline at 3, 6 and 12 months |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| New York Heart Association (NYHA) Classification | Week:4 | — |
| re-hospitalization | Change from Baseline at 3, 6 and 12 months | Heart failure with re-hospitalization is documented by at least one of the following: worse exercise tolerance and respiratory distress with NYHA class III or IV symptoms, presence of pulmonary rales, or chest radiography showing pulmonary congestion, which needs an augmented decongestive regimen with oral or intravenous medications during an in-hospital stay. |
| plasma brain natriuretic peptide (BNP) concentration | Week:4 | — |
| Cardiovascular death | Change from Baseline at 3, 6 and 12 months | — |
| Cardiac transplantation | Change from Baseline at 3, 6 and 12 months | — |
Countries
China
Outcome results
None listed