Familial Analysis of Keratoconus Risk

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02812563

Acronym

AFRIK

Enrollment

Registered

2016-06-24

Start date

2014-11-25

Completion date

2017-09-19

Last updated

2017-11-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Keratoconus

Brief summary

The principal objective of this study is to evaluate the frequency of KC inside family of patients with confirmed KC. It's a familial, epidemiological, prospective, single-center study.

Detailed description

Keratoconus is a common bilateral progressive corneal ectatic disease causing visual impairment by inducing irregular astigmatism and corneal opacities. This disorder typically begins during teenage years, progresses until the age of 30 to 40 years and, in severe forms, may need a corneal transplantation. Currently, keratoconus has not known etiopathogenesis, and it is difficult to detect subclinical forms. Several risk factors seem to be implied, environmental and genetic : the risk of keratoconus in case of familial history of keratoconus isn't well known at that time, but seems to be important to consider to promote screening and follow up of patient with a familial history of keratoconus (KC).

Interventions

OTHERgenetic

Galilee exam - Corn analysis with Optiwave Refractive Analysis

Study design

Observational model

FAMILY_BASED

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

7 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

Case : * patient carrier of keratoconus * more than 7 years * patient who didn't expressed opposition as for computerization and use of data concerning him Family of case * to have a first degree family member (father, mother, brother, sister, child) carrier of keratoconus * more than 7 years * patient who didn't expressed opposition as for computerization and use of data concerning him

Exclusion criteria

* ocular pathology or antecedent of modification of cornea (surgery, traumatism, ocular hypertension, keratitis) which could interfere with topographical analysis * wearing of rigid contact lens for 15 days before exams, or flexible lens for 5 days before exams

Design outcomes

Primary

Measure	Time frame
proportion of diagnosed keratoconus	1 day

Secondary

Measure	Time frame
Assesment of familial history on KC severity	1 day
Evaluation of KC severity	1 day

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026