Retinal Disease
Conditions
Brief summary
Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases
Detailed description
Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.
Interventions
DEVICEoptical coherence tomography angiography
Imaging with optical coherence tomography angiography
Sponsors
Insel Gruppe AG, University Hospital Bern
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Patients from the Department of Ophthalmology, University Hospital Bern requiring conventional imaging for eye disease and willing to sign informed consent Patients of 18 years or older
Exclusion criteria
Patients not willing or able to sign informed consent Patients younger than 18 years Patients with epilepsy Patients having had photodynamic therapy within the last 48 hours prior to imaging with OCTA
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the sensitivity and specificity of OCTA | 2 years | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of the intra-and inter-reader reproducibility of the diagnosis of vascular abnormalities using OCTA | 2 years | The primary objective of this observational study is to evaluate the sensitivity and specificity to diagnose vascular abnormalities with OCTA compared to conventional imaging methods. The main parameter that will be assessed is area of nonperfusion of the retina. The incidence (binary) of nonperfusion areas will be assessed in OCTA and compared to conventional imaging methods such as fluorescein angiography. |
| OCTA and Fundus color photographs | 2 years | Evaluation whether pathological changes seen in OCT or color fundus photography correlate with changes seen in OCTA |
| Subgroup analysis | 2 years | Subgroup analysis will be performed with patients suffering from diabetic retinopathy, artery occlusion, carotid stenosis, retinal detachment, vein occlusion, age related macular degeneration, retinal changes from arterial hypertension, retinal macroaneurysms and uveitis. |
Countries
Switzerland
Outcome results
None listed