Infant, Premature
Conditions
Keywords
neurological, difficulties
Brief summary
A total of 40% of neurodevelopmental difficulties have been reported in very premature infants less than 32 weeks of age. The Epipage1 study reported a decreasing prevalence of cerebral palsy (9-6%) but a high prevalence of specific cognitive neurological difficulties and an increase in school failure. Neurocognitive difficulties are numerous: visuospatial dyspraxia, language disorders, executive function disorders as well as attention and behaviour disorders. Developmental language disorders have been rarely reported in the literature. This originally prompted our request i.e. PHRC 2010 National Multicenter: LAMOPRESCO. For the past 3 years this protocol has studied the language development of children who were born very prematurely, aged 3 and a half years free of cerebral palsy, in particular the impact of a short rehabilitation period, precise, at an early stage, and protocolized on a fundamental sensorimotor language. The principal assessment criterion was the measurement of phonology, the cornerstone of oral and written language in humans. The aim of the present project is an analysis of the effect that this specific language stimulation has on the learning of written language. The hypothesis is that a specific work modifying various aspects of a child's language, during the age of 3 to 4, alters the development of phonological skills in a sustainable way. The acquisition of reading skills is basically dependent on the quality of its phonological components. The randomized study of children up to 8 years of age in a cohort of 150 children (LAMOPRESCO) will permit to confirm or refute this hypothesis. These increasing difficulties have been reported as regards the language understanding of 3 to 15 year old children. It is as if the initial difficulties and weaknesses, which moreover constituted oral language, prevented the use or development of neural networks, which became more complex and required both an oral and written language. Are these elements which constitute phonology, at an early stage, modifiable before the close of the clinically measurable developmental window?
Interventions
BEHAVIORALmeasurement of phonology
measurement of phonology will be assess using BILO-3, EDA, VS and VL tests
Sponsors
University Hospital, Rouen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Eligibility
Sex/Gender
ALL
Age
8 Years to 8 Years
Healthy volunteers
No
Inclusion criteria
* Randomization in LAMOPRESCO-1 study
Exclusion criteria
* None as the same population as in the LAMOPRESCO study will be included
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of reading speed | Day 1 | Evaluation of reading speed will be assess using silent reading speed test. Patient must read a list of words during 2 minutes. The total number of read words will be analyse to calculate the reading speed. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Evaluation of syntax level | Day 1 | Patient must read a list of words during 2 minutes and select how much words are not correctly written. |
| Evaluation of vocabulary level, syntax and understanding | Day 1 | Patient must read a list of words during 2 minutes and select how much words are not correctly written. |
| Evaluation of understanding level | Day 1 | Patient must read a text and then answer oral questions about the history read. |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORAude CHAROLLAIS, MD
University Hospital, Rouen
Outcome results
None listed