Aging, Menopause
Conditions
Keywords
Gonadal hormones, Gonadotropins, Cardiovascular diseases, Lipids, Obesity, Atherosclerosis, Glucose metabolism disorders, Metabolic syndrome, Non-alcoholic fatty liver disease
Brief summary
Deficiency in gonadal hormone has been considered to play a role in ageing related increased incidence of cardiovascular events. But the mechanism has not been fully elucidated. On the other hand, the dramatic increase in gonadotropin level didn't drew much attention when talking about the increased risk of cardiovascular disease during menopausal transition. This study aim to investigate the association between gonadal hormone, gonadotropin and long-term cardiovascular events.
Interventions
None listed
Sponsors
Shandong Provincial Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female with intact uterus and at least one ovary * Aged of 18 to 75 years old;
Exclusion criteria
* Pregnancy or lactation women; * Presence of pituitary/hypothalamic disorders, polycystic ovarian syndrome or other endocrinal and metabolic disorders that known to compromise hypothalamic-pituitary-gonadal function; * Receiving psychotropic or hormonal medications including hormonal contraception and hormone therapies; * Taking lipid-lowering agents or hypoglycemic agents and other drugs that known to influence cardiovascular health; * Obviously poor compliance.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| All-cause mortality | Measured after 10 years of follow-up | Total deaths from all causes over a given period of time |
| Rate of first cardiovascular disorder events | Measured after 10 years of follow-up | Total incidence rate from cardiovascular disorder over a given period of time |
| Cardiovascular disease mortality | Measured after 10 years of follow-up | Total deaths from cardiovascular disease over a given period of time |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in serum lipid levels | Measured at baseline, and every 2 years during the 10-year follow-up period | Include triglycerides、cholesterol、 low density lipoprotein cholesterol、 high density lipoprotein cholesterol. |
| Number of participants that diagnosed with non-alcoholic fatty liver disease | Measured at baseline, and every 2 years during the 10-year follow-up period | A clinicopathological syndrome characterized by excessive deposition of fat in liver cells due to alcohol and other clearly damaging factors is excluded |
| Change in thickness of blood vessel wall | Measured at baseline, and every 2 years during the 10-year follow-up period | The mean carotid Intima media thickness showed the early risk of atherosclerotic cardiovascular diseasean. the subclinical atherosclerosis was defined as the mean carotid Intima media thickness ≥0.78mm. |
| Number of participants that diagnosed with metabolic syndrome | Measured at baseline, and every 2 years during the 10-year follow-up period | Metabolic syndrome refers to the pathological state in which protein, fat, carbohydrate and other substances in human body have metabolic disorders. It is a group of complex metabolic disorders and a risk factor leading to cardiovascular and cerebrovascular diseases of diabetes. |
Countries
China
Outcome results
None listed