Bony Defects
Conditions
Brief summary
Background: the ultimate goal of periodontal therapy is the regeneration of periodontal tissues. Researches had demonstrated the benefits of platelet concentrates bine grafts in osseous regeneration in the areas of periodontal surgery. Aim of the study: to evaluate the effect of PRF with/without nanohydroxyapatite in periodontal intrabony defects.
Detailed description
Background: the ultimate goal of periodontal therapy is the regeneration of periodontal tissues. The regenerative and wound healing potential of platelets has attracted much attention over the last few years. Researches had demonstrated the benefits of platelet concentrates in osseous regeneration in the areas of periodontal surgery and implantology. In addition, nanohydroxyapatite was shown to be unsheathed by newly formed bone and partly replaced by it, but resorbed very slowly, as shown in animal experiments after 9 months or in clinical studies after a 6-month observation period. The clinical and biochemical studies evaluating the regenerative effect of PRF alone or in combination with nanohydroxyapatite in periodontal intrabony defects are still deficient. Aim of the study: to evaluate clinical and biochemical effect of PRF with/without nanohydroxyapatite in treatment of human intrabony defects.
Interventions
PROCEDUREOFD alone
Periodontal surgical cleaning procedure
DRUGPlatelet rich Fibrin
Natural platelet concentrate rich in growth factors
DRUGNanohydroxyapatite
Synthetic bone graft
Sponsors
King Abdulaziz University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* All patients are free from systemic illness. * All patients should be diagnosed as having chronic periodontitis. * Patients should be cooperative, motivated and willing to follow our treatment protocol and follow up visits. * Patients selected had not received antibiotics or anti-inflammatory therapy in the 6 months prior to examination.
Exclusion criteria
* Presence of areas of periodontal pocket of (probing depth ≥5 and clinical attachment level (CAL) ≥ 3). * Patients who have received any type of periodontal treatment in the past 6 months prior to examination.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Gingival crevicular fluid (GCF) | up to 3 weeks. | GCF will be collected after removing saliva and supra-gingival plaque using methylcellulose filter paper strip that will be inserted in the periodontal pocket and will be let in for 30 seconds. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Changes in Gingival index | up to 3 months | Gingival index (GI) developed on 1963. |
| Changes in level of attachment loss | up to 3 months | Attachment loss: will be measured from the cemento-enamel junction (CEJ) to the apical part of the sulcus. |
| Changes in probing pocket depth | up to 3 months | Probing pocket depth (PD): six measurements per tooth will be recorded by using the University of Michigan O periodontal probe with Williams markings. |
Countries
Saudi Arabia
Outcome results
None listed