General Glucocorticoid Resistance
Conditions
Brief summary
As the investigators observed a case of glucocorticoid mutation revealed by incidentally discovered bilateral adrenal nodular hyperplasia, it was postulated that this molecular anormality could be more frequent than previously described. To validate this hypothesis, it was decided to study 150 multicenter consecutive patients, presenting with incidentally discovered bilateral adrenal masses without clinical signs of Cushing's disease. In all these patients GR gene will be studied, mutations will be detected and described, functional disturbance will be tested. Usual polymorphisms will be described. Correlation between clinical signs, hormonal and morphological abnormalities and presence or absence of GR mutations will be searched.
Interventions
GENETICblood collection for mutation characterization
Sponsors
CHU de Reims
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patients more than 18 years of age * patients with bilateral adrenal masses
Exclusion criteria
* Refusing to participate in the study * Protected by law * Have obvious signs of Cushing's syndrome * No progressive neoplastic disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| frequency of mutations | DAY 0 |
Countries
France
Outcome results
None listed