Cardiometabolic Health, Cognitive Function
Conditions
Keywords
Omega-3, Child nutrition, Dietary recommendations, Cardiovascular risk markers, Cognitive function, Mental health
Brief summary
The purpose of FiSK Junior is to investigate whether intake of oily fish compared to poultry affects cardiovascular risk markers, cognitive function, and behaviour in healthy children.
Detailed description
The FiSK Junior study compares the effects of consuming oily fish versus poultry (control) in healthy 8-9 year-old Danish children. The children will be randomized to consume approximately 300 g/week of either oily fish or poultry for 12 weeks. Measurements and biological sampling will be performed at baseline and at the end of the intervention. The main objective of the study is to investigate the effect on cardiovascular risk markers, primarily blood pressure and plasma triacylglycerol. Moreover, the effects on cognitive function, behaviour, emotions and physiological stress response will be assessed. In addition, change in n-3 long chain polyunsaturated fatty acid status (compliance), anthropometry, body composition, vitamin D status, inflammatory markers, growth markers, physical activity and diet will be measured. Outcomes will be analysed with focus on potential gender- and genotype-specific effects.
Interventions
DIETARY_SUPPLEMENTOily fish
A selection of oily fish, including salmon, herring and mackerel, provided for dinner and lunch
DIETARY_SUPPLEMENTPoultry
A selection of poultry, mainly chicken, provided for dinner and lunch
Sponsors
Aalborg University Hospital
University of Waterloo
University of Copenhagen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
8 Years to 9 Years
Healthy volunteers
Yes
Inclusion criteria
Children must: * Be 8 - 9 years of age at the start of the intervention * Be healthy * Like oily fish and chicken * Be willing to be randomized to eat fish or chicken * Not consume oily fish more than once per week 3 months prior to intervention start * Not consume fish oil 3 months prior to intervention start * Speak Danish in order to understand the study procedures Moreover: * Parents must read and speak Danish, in order to be properly informed about the study procedures * The child must live in a household with ≤5 persons
Exclusion criteria
* Serious chronic illnesses and diseases that may interfere with study outcomes * Diagnosed Attention Deficit Hyperactivity Disorder (ADHD) or other psychiatric illness * Intake of medication that may affect study outcomes * Concomitant participation in other studies involving dietary supplements or blood sampling * Living in a household with another participating child
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum triacylglycerol concentration | At 12 weeks | Fasting blood level |
| Blood pressure | At 12 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Heart rate | At 12 weeks |
| BMI z-score | At 12 weeks |
| Waist circumference | At 12 weeks |
| Serum HDL cholesterol | At 12 weeks |
| Blood glycosylated haemoglobin (HbA1c) | At 12 weeks |
| Response inhibition measured by Flanker test | At 12 weeks |
| Selective attention capacity measured by Stroop Test | At 12 weeks |
| Attention measured by the D2 Test of Attention | At 12 weeks |
| Saliva cortisol after cold-pressor task | At 12 weeks |
| Hair cortisol | At 12 weeks |
| Compliance measured by content of n-3 long-chain polyunsaturated fatty acids in red blood cells | At 12 weeks |
| Fat mass index by bioimpedance | At 12 weeks |
| Plasma glucose | At 12 weeks |
| Serum insulin | At 12 weeks |
| Serum LDL cholesterol | At 12 weeks |
| Cognitive function measured by the Cambridge Neuropsychological Test Automated Battery | At 12 weeks |
Other
| Measure | Time frame | Description |
|---|---|---|
| Serum insulin-like growth factor-1 | At 12 weeks | — |
| Serum C-reactive protein | At 12 weeks | — |
| Serum 25-hydroxy-vitamin D | At 12 weeks | — |
| Physical activity | At 12 weeks | Measured by accelerometry |
| Behaviour measured by the Strengths and Difficulties Questionnaire | At 12 weeks | Administered to parent |
| Behaviour measured by the Behavior Rating Inventory of Executive Function Questionnaire | At 12 weeks | Administered to parent |
Countries
Denmark
Outcome results
None listed