The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of PONV

The Effects of Anesthetic Techniques and Palonosetron Administration on the Incidence of Postoperative Nausea and Vomiting in the Women Patients Undergoing Thyroidectomy

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02809378

Enrollment

150

Registered

2016-06-22

Start date

2016-06-30

Completion date

2017-04-20

Last updated

2017-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesia, Palonosetron, PONV

Brief summary

The incidence of postoperative nausea and vomiting (PONV) after thyroidectomy have been shown to be relatively high compared other surgeries, with a reported incidence 65-75 %. PONV may increase patient discomfort, delay patient discharge, and increase the cost of patient care, the risk of postoperative bleeding which may potentially cause airway obstruction. It is reported that the maintenance of anesthesia with propofol-remifentanil or sevoflurane-propofol-remifentanil decreased the incidence of PONV compared sevoflurane alone, but failed to demonstrate the decreased incidence of PONV in 6-24 hr postoperative period in patients undergoing thyroidectomy. Administration of Palonosetron, newly developed 5-HT3 antagonists with long half life (48 hrs) may decrease the incidence of PONV particularly during this period. The purpose of this study was to evaluate and compare the incidence of PONV after thyroidectomy with three different anesthetic methods, sevoflurane or sevoflurane-propofol-remifentanil or sevoflurane-propofol-remifentanil-palonosetron in woman patients.

Interventions

DRUGPalonosetron

newly developed 5-HT3 antagonists with long half life (48 hrs) intravenous administration prior to anesthesia induction

DRUGsevoflurane

Inhalational anesthetics Halogenated.

DRUGremifentanil

ultra-short acting opioid anesthetics

DRUGpentothal sodium

intra-venous anesthetics for anesthesia induction

DRUGpropofol

intra-venous anesthetics for anesthesia induction and maintenance

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender

FEMALE

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* patients undergoing thyroidectomy euthyroid status American Society of Anesthesiology Physical status 1,2

Exclusion criteria

* Ideal body weight \>130% gastrointestinal disease prior administration of anti-emetics (24hr)

Design outcomes

Primary

Measure	Time frame
incidence of postoperative nausea and vomiting	24 hour postoperative

Secondary

Measure	Time frame
incidence of postoperative nausea and vomiting	at immediate postoperative

Countries

South Korea

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026