Contrast-induced Acute Kidney Injury, Microalbuminuria
Conditions
Keywords
coronary angiography, contrast-induced acute kidney injury, microalbuminuria
Brief summary
The purpose of this study is to investigate the association between pre-existing microalbuminuria and contrast-induced acute kidney injury (CIAKI) following coronary angiography (CAG).
Interventions
Sponsors
Study design
Eligibility
Inclusion criteria
* Patients with eGFR≥30ml/min and without macroalbuminuria undergoing CAG.
Exclusion criteria
* Pregnancy * Lactation * Allergic history of contrast media * Having been received contrast media within 7 days * Use of nephrotoxic medications within 7 days * eGFR \<30 ml/min, macroalbuminuria (ACR \>300 mg/g) * Renal transplantation, emergent coronary angiography * Cardiogenic shock, pulmonary edema * Use of intra-aortic balloon pump (IABP) or mechanical ventilation * Multiple myeloma and other malignant tumor * Life expectancy less than 12 months
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| changes of serum creatinine (SCr, umol/L) | 24-48 hours after CAG | the difference of SCr before and after CAG. |
| number of participants with increase in SCr of at least 44.2 umol/L higher than before | 24-48 hours after CAG | number of participants with the difference of SCr before and after CAG over 44.2 umol/L. |
| number of participants with increase of SCr over 25% higher than before | 24-48 hours after CAG | number of participants with an increase of SCr over 25% higher than before. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| changes of urine albumin to creatinine ratio (ACR, mg/g) | 24-48 hours after CAG | the difference of ACR before and after CAG |
Countries
China