The Risk Factors of Symptomatic Gallbladder Stone: Age-Sex Matched Case-control Study Performed in Single Institute

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02808546

Enrollment

342

Registered

2016-06-21

Start date

2009-01-31

Completion date

2015-12-31

Last updated

2016-06-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gallstone

Keywords

Gallbladder stone, Risk factor, Case-control study, Obesity, Hypertension, Alcohol consumption

Brief summary

The main purpose of this study is to investigate the region-specific cause of gallbladder stone incidence in Jeju Self-Governing Province, Korea.

Detailed description

Investigators performed the epidemiologic study to uncover the reason of relatively higher incidence of Gallbladder cancer in small isolated island, Jeju island, one of small province among 11 self governing area in South Korea. Tow studies, including descriptive epidemiology and analytic epidemiology using case-control study, some risk factors were obtained regarding Gallbladder cancer development in this area. Old age, female, and gallstone were potential risk factors and alcohol consumption was preventive factors. So authors decided to evaluate the relationship between alcohol and gallbladder stone in order to how much portion of causal relationship they have with gallbladder cancer. So this study was designed to investigate the relationship between gallbladder stone and alcohol consumption then performed clinical based case-control study with age-sex matching to each subjects.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Healthy volunteers

Inclusion criteria

Case group Inclusion Criteria: * Clinical diagnosis of gallstone disease after cholecystectomy.

Exclusion criteria

* Ambiguous diagnosis cases for gallbladder stone. * Incomplete medical record. Control group Inclusion Criteria * Healthy examinees in Health Promotion Center in same Institute * Eligible cases of abdominal ultrasound(US) or computed tomography(CT)

Design outcomes

Primary

Measure	Time frame	Description
Alcohol consumption	Through study completion, an average of 1 year	Standard Dose Drink per week was used to compare the amount of alcohol consumption of each subjects

Secondary

Measure	Time frame	Description
Obesity	Through study completion, an average of 1 year	Obesity was defined as cases were scored more than 25 kg/square meter of Body Mass Index

Outcome results