Hypertrophic Cardiomyopathy Pilot Study

Pilot Observational Case-control Study of the Electrical Heterogeneity in Patients With Hypertrophic Cardiomyopathy and High Arrhythmic Risk

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02806479

Enrollment

Registered

2016-06-20

Start date

2016-09-30

Completion date

2020-09-30

Last updated

2020-09-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary Artery Disease, Hypertrophic Cardiomyopathy

Brief summary

This study evaluates mechanisms of arrhythmogenicity in hypertrophic cardiomyopathy, in comparison to patients with well-understood arrhythmogenic substrate (ischemic cardiomyopathy), as well as to individuals free from arrhythmogenic substrate

Interventions

OTHERObservational: Arrhythmogenic Substrate

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Inclusion criteria

* Diagnosed HCM * Documented history of sustained ventricular tachyarrhythmia or resuscitated sudden cardiac arrest * Maximal left ventricular wall thickness of \> 30mm * Extensive fibrosis on cardiac MRI (\>15% of total myocardial volume) * \>7.5%/5-year risk of sudden cardiac death as determined by HCM risk-SCD

Exclusion criteria

* age \< 18 years * Pregnancy * Atrial Fibrillation

Design outcomes

Primary

Measure	Time frame
Non-invasively reconstructed epicardial activation map	within one day

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 18, 2026