Cerebral Infarction
Conditions
Keywords
cerebral infarction, kallikrein, KLK
Brief summary
Evaluate the effectiveness of the of kallikrein in the different drug frequency for acute anterior circulation cerebral infarction.
Interventions
DRUGHuman Urinary Kallidinogenase for Injection
Patients need to complete laboratory tests within a specified time and to complete the experimental requirements of medication time
Sponsors
Huisheng Chen
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1. Age 18 to 80 years old; 2. First time diagnosed or have history of acute anterior circulation cerebral infarction without serious sequelae (mRS = 0-2); 3. Acute anterior circulation cerebral infarction with large artery atherosclerotic etiology; 4. Ability to randomize within 48 h of time last known free of new ischemic symptoms. 5. National Institute of Health stroke scale(NIHSS) ranges from 7 to 22; 6. signed written informed consent.
Exclusion criteria
1. Cerebral CT shows cerebral hemorrhage disease: cerebral hemorrhage, subarachnoid hemorrhage, etc.; 2. Transient ischemic attack; 3. Serious disturbance of consciousness: Glasgow Coma ScaleGCS（GCS）≤8; 4. Combined angiotensin-converting enzyme inhibitor(ACEI) less than 5 half-time (according to its instruction), or need to be treated with ACEI; 5. Past or present suffering from hemorrhagic tendency of the disease; 6. The investigator in consideration of the other condition that the patients doesn't fit to participate in this clinical study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the decrease of National Institute of Health stroke scale(NIHSS) | 14 Days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| the Barthel Index | 90 Days | — |
| the Modified Rankin Scale | 90 Days | — |
| change of the National Institute of Health stroke scale | 8 Days | — |
| the composite of ischemic vascular events | 90 Days | ischemic stroke, MI, or ischemic vascular death |
Countries
China
Contacts
Primary ContactHuisheng Chen
Backup Contactzhonghe Zhou
Outcome results
None listed