Gastric Intestinal Metaplasia
Conditions
Brief summary
Investigators found that the degree and the duration of aceto-whitening differed between gastric intestinal metaplasia(GIM) and the surrounding normal mucosa: the area of GIM showed a severe degree of aceto whiteness and the whitening continued longer than the surrounding normal mucosa, which investigators called severe whitening and delayed fading, and investigators realized that GIM could possibly be diagnosed by using these differences.The aim of this prospective study was to investigate the efficacy of severe whitening and delayed fading for diagnosing GIM.
Interventions
PROCEDUREacetic acid-enhanced endoscopy
Acetic acid-enhanced endoscopy combines conventional endoscopy with the instillation of acetic acid.
DRUGAcetic Acid
The concentration of acetic acid used in this study is 1.5%.
DEVICEendoscope
This study using an EG-29-i10 endoscope (Pentax, Tokyo, Japan) and an EPK-i7010 processor (Pentax, Tokyo, Japan).
Sponsors
Shandong University
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
* long-lasting upper gastrointestinal symptoms (\>15 years) * atrophic gastritis or GIM identified at surveillance endoscopy
Exclusion criteria
* presence of advanced adenocarcinoma in the stomach * presence of acute gastrointestinal bleeding * presence of coagulopathy, uncontrolled impaired renal or liver disease * presence of pregnancy or lactation * presence of allergy to acetic acid * age younger than 18 years or older than 80 years * inability to provide written informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| accuracy of severe whitening for diagnosing gastric intestinal metaplasia | 6 months |
| accuracy of delayed fading for diagnosing gastric intestinal metaplasia | 6 months |
Countries
China
Contacts
Primary ContactXiuli Zuo, PhD
Outcome results
None listed