Chronic Kidney Disease
Conditions
Keywords
chronic kidney disease, malnutrition inflammation atherogenesis syndrome, muscle strength, muscle mass, lean body mass, physical activity
Brief summary
Aim of this study is to determine in chronic kidney disease patients: * the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment * the relationship between voluntary muscle strength and muscle mass * the relationship between voluntary muscle strength and lean body mass * the correlation between voluntary muscle strength and physical activity
Detailed description
Aim of this study is to determine in chronic kidney disease patients: * the involvement of malnutrition inflammation and atherogenesis syndrome (increase in C reactive protein and decrease in serum albumin) on voluntary muscle strength impairment (estimated by handheld dynamometer) * the relationship between voluntary muscle strength and muscle mass (estimated by creatinine index) * the relationship between voluntary muscle strength and lean body mass (estimated by bioelectrical impedance analysis) * the correlation between voluntary muscle strength and physical activity (the physical activity being estimated by the Voorrips score questionnaire)
Interventions
DEVICEHandheld dynamometer
Evaluation of muscle strength
BIOLOGICALCreatinine index
Evaluation of muscle mass using plasma creatinine level
DEVICEElectrical bioimpedance analysis
Evaluation of lean body mass
OTHERVoorrips score questionnaire
Evaluation of physical activity
BIOLOGICALInflammatory and nutritional status
Evaluation of C reactive protein and albumin
Sponsors
University Hospital, Montpellier
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* chronic kidney disease patient with extrarenal replacement therapy by hemodialysis for at least 3 months * stable clinical condition (absence of infection, stroke or acute decompensation)
Exclusion criteria
* chronic kidney disease without extrarenal replacement therapy * history of renal transplantation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Voluntary muscle strength evaluated by handheld dynamometer | 1 day | data will be measured in Newton.meter |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Muscle mass estimated by creatinine index evaluation | 1 day | data will be obtained from plasma creatinine level and will be expressed in milligram/kilogram/day) |
| Lean body mass evaluated by electrical bioimpedance analysis | 1 day | data will be expressed in kilogram |
| Physical activity estimated using the Voorrips score questionnaire | 1 day | the score represents the daily physical activity according to a validated scale |
| C reactive protein level | 1 day | the parameter will be measured in milligram/liter |
| Albumin level | 1 day | the parameter will be measured in gram/liter |
Countries
France
Outcome results
None listed