Comparison of the Hemodynamic Safety of Two Common Alveolar Recruitment Manoeuvres With Regard to Cardiac Output in a Surgical Intensive Care Unit

Comparison of the Hemodynamic Safety of Two Common Alveolar Recruitment Manoeuvres With Regard to Cardiac Output in a Surgical Intensive Care Unit: a Randomized Study

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02805036

Acronym

RHERA1

Enrollment

Registered

2016-06-17

Start date

2015-11-30

Completion date

2016-11-30

Last updated

2017-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Positive-Pressure Respiration

Keywords

alveolar recruitment, stroke volume/physiology, cardiac output/physiology

Brief summary

Protective ventilation - combining a low tidal volume (between 6 and 8 ml/kg) and alveolar recruitment (AR) manoeuvres repeated every 30 minutes - is currently the standard of care for decreasing morbidity associated with mechanical ventilation. In contrast, there is no consensus on the type of recruitment manoeuvre, which varies from one centre to another and from one study to another. The investigators intend to compare two currently used AR techniques with regard to their ventilatory efficacy and hemodynamic safety: * An end-tidal plateau at 30 cmH20 for 30 seconds. * An end-tidal plateau at 10 cmH20 above the patient's plateau pressure for 30 seconds, without exceeding 30 cmH20.

Interventions

DEVICEechocardiography

• Prospective, simultaneous recording of the cardiac output (measured non-invasively via transthoracic echocardiography) and a number of parameters commonly monitored in the surgical intensive care unit (CVP, SBP/DBP/MBP).

DEVICEArterial oximetry

measured by co-oximetry of a blood sample taken via the arterial catheter implemented for critical care

Study design

Observational model

CASE_CONTROL

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* All sedated, intubated, mechanically ventilated adult patients (over-18) admitted to the surgical intensive care unit and equipped with a central venous catheter and an arterial catheter. * Good echogenicity * Social security coverage

Exclusion criteria

* Pregnancy * Cardiac arrhythmia * Poor echogenicity * Legal guardianship or incarceration * Systolic blood pressure ≤90 mmHg * Respiratory distress * Patients admitted on an emergency basis (first 24 hours), i.e. not for elective surgery

Design outcomes

Primary

Measure	Time frame
Variations in cardiac output induced by each type of AR manoeuvre	Day 0

Secondary

Measure	Time frame
Variations in PaO2 variations induced by each type of AR manoeuvre	Day 0

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026