Obstetrical Complication of Anesthesia
Conditions
Keywords
reactive oxygen species, elective cesarean section, oxygen therapy, newborn
Brief summary
In this study the investigators examine the effects of intraoperative oxygen administration to the mother on certain enzyme functions of the newborn. With this object blood samples are taken from the newborn's umbilical chord - which is otherwise a routine practice at the investigators clinic - and the mother's radial artery in parallel with umbilical clamping and cutting for blood gas and reactive oxygen species analyses. Samples are analyzed locally in a properly equipped laboratory.
Detailed description
Whole-blood superoxide and hydrogen peroxide production was measured from the newborn's umbilical chord.
Interventions
OTHEROxygen
Oxygen administration
Sponsors
Szeged University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Elective cesarean section. * Signed informed consent form.
Exclusion criteria
* Subject meets the definition of a vulnerable subject as defined in International Organization for Standardization 14155:2011.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Hyperoxia Newborns | through study completion up to two years | We measured umbilical vein blood gas parameters. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Maternal hyperoxia | through study completion up to two years | We measured arterial blood gas parameters of the mother from radial artery. |
| Alterations in newborns' enzyme functions due to maternal hyperoxia | through study completion up to two years | We measured umbilical vein reactive oxygen species (ROS) of the newborn. |
Countries
Hungary
Outcome results
None listed