Chronic Respiratory Failure, Exercise Endurance, Nasal High Flow Therapy, Rehabilitation
Conditions
Keywords
nasal high flow therapy, rehabilitation, exercise endurance
Brief summary
The purpose of this study is to compare the exercise endurance between oxygen therapy with rehabilitation and nasal high flow therapy with rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.
Detailed description
In patients with chronic respiratory failure, pulmonary rehabilitation is recognized as an evidence-based treatment in improving exercise capacity, muscle strength, dyspnea, and quality of life. Oxygen supplementation during exercise induced dose-dependent improvement in endurance and symptom perception in chronic obstructive pulmonary disease patients. Recently, nasal high flow therapy which consists of high flow gas with an FiO2 ranging from 0.21 to nearly 1.0 adjusted by an oxygen blender, brought to body temperature, and saturated with water through an in-line humidifier is available. The present study is randomised to compare the effect of exercise endurance between oxygen therapy with rehabilitation and nasal high flow therapy with rehabilitation for the patients with chronic respiratory failure receiving long-term oxygen therapy.
Interventions
DEVICEnasal high flow therapy
The nasal high flow therapy has enabled high flow oxygen to be derived through nasal cannula. This mode not only allows constant FiO2 during peak inspiratory flow but also confers benefits including a low level of continuous positive airway pressure with increased end-expiratory lung volume and reduced work of breathing, partly through intrinsic positive end-expiration pressure compensation and dead space washout. The inspired gases are warmed and humidified, improving comfort and possibly reducing airway inflammation, leading to improved drainage of respiratory secretions.
Sponsors
National Hospital Organization Minami Kyoto Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Subjects with chronic respiratory failure receiving long-term oxygen therapy for more than 3 months.
Exclusion criteria
* Subjects with severe cardiovascular disease, diabetes, neurological disease, and renal failure. * Subject who are unable to undergo rehabilitation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Walk distance (measured by six minutes walking test) | Four weeks |
Secondary
| Measure | Time frame |
|---|---|
| Exercise tolerance test (exercise time et.) | Four weeks |
| Body composition measured by InBody (muscle mass et.) | Four weeks |
| Arterial blood gas | Four weeks |
| Six minutes walking test (minimum Oxygen Saturation of Arterial Blood Measured by Pulse Oximeter (SpO2) et.) | Four weeks |
| Nutritional status (body mass index(kg/m2) et.) | Four weeks |
| Sympathetic activity (Catecholamine et.) | Four weeks |
| Dyspnea (Modified Borg scale) | Four weeks |
| Inflammation (CRP et.) | Four weeks |
Countries
Japan
Outcome results
None listed