Robot-assisted Laparoscopic Radical Prostatectomy Undergoing General Anesthesia
Conditions
Keywords
robot-assisted laparoscopic radical prostatectomy, Autoflow, trendelenburg position, pneumoperitoneum
Brief summary
The steep trendelenburg position and pneumoperitoneum during laparoscopic surgery have the potential to cause an adverse effects on respiratory mechanics and gas exchange. Autoflow-volume controlled ventilation may improve lung compliance and reduce airway peak pressure. Therefore, the aim of this study is to evaluate whether Autoflow-volume controlled ventilation improves gas exchange and respiratory mechanics in patients undergoing robot-assisted laparoscopic radical prostatectomy.
Interventions
During anesthesia and surgical procedure, volume-controlled ventilation will be applied with an inspiration:expiration ratio of 1:2 and a tidal volume of 8 mL per ideal body weight (kg) without ventilatory mode change.
After tracheal intubation, volume-controlled ventilation will be initiated with an I:E ratio of 1:2 and a tidal volume of 8 mL per ideal body weight (kg). Immediately after CO2 pneumoperitoneum with steep Trendelenburg positioning, Autoflow-volume controlled ventilation will be applied instead of volume-controlled ventilation. Immediately after CO2 desufflation and supine positioning, volume-controlled ventilation will be applied again.
Sponsors
Yonsei University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to 80 Years
Healthy volunteers
No
Inclusion criteria
1\. Adult male patients scheduled for elective robot-assisted laparoscopic radical prostatectomy undergoing general anesthesia
Exclusion criteria
1. chronic obstructive respiratory diseases 2. heart failure 3. body mass index (BMI \>30 kg/m2)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| arterial oxygen tension (PaO2) | 30 minutes after steep trendelenburg position and pneumoperitoneum. | Arterial oxygen tension (PaO2) obtained from arterial blood gas analysis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The peak inspiratory pressure | 10 minutes after anesthesia induction, 30 and 60 minutes after steep trendelenburg position and pneumoperitoneum, and 10 minutes after supine position and CO2 desufflation. | The peak inspiratory pressure during mechanical ventilation with endotracheal intubation under general anesthesia |
Countries
South Korea
Outcome results
None listed