Acute Kidney Injury
Conditions
Keywords
partial nephrectomy, acute kidney injury, LiDCOrapid, circulatory management
Brief summary
The purpose of this study is to investigate whether circulatory management based on LiDCOrapid hemodynamic monitoring can reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy when compared with routine circulatory management based on blood pressure and urine output monitoring
Detailed description
Previous studies found that the incidence of acute kidney injury afer partial nephrectomy is higher than 30%. In addition to nephron loss induced by renal parenchyma resection, ischemia/reperfusion injury produced by clamping/unclamping of renal arteries is also an important reason. However, studies investigating the effect of circulatory management on the incidence of acute kidney injury after partial nephrectomy are limited. It has been shown that perioperative hemodynamic optimization protected renal function in surgical patients. And in patients undergoing renal transplantation, adequate hydration and optimal perfusion enhances early graft function. The investigators hypothesize that hydration and circulatory management to guarantee optimal renal perfusion may decrease the occurrence of acute kidney injury after partial nephrectomy. The purpose of this study is to investigate whether circulatory management based on LiDCOrapid hemodynamic monitoring can reduce the incidence of acute kidney injury in patients undergoing partial nephrectomy when compared with routine circulatory management based on blood pressure and urine output monitoring.
Interventions
OTHERGoal-directed circulatory management
In addition to routine monitoring, invasive LiDCOrapid is used to monitor MAP, SVV and CI. Intraoperative circulatory management is performed according to the goal-directed principal, i.e., to maintain MAP \> 95 mmHg, SVV \< 6%, and CI 3.0-4.0 L/min/m2, started from renal artery clamping and maintained until the end of surgery. Crystalloid solution is firstly infused to maintain SVV at the target level, dobutamine and/or noradrenaline are then infused to maintain MAP and CI at the target levels.
OTHERRoutine circulatory management
Routine monitoring is performed, which include invasive blood pressure and urine output. Intraoperative circulatory management is performed according to routine practice, i.e., to maintain blood pressure within 20% from baseline level and urine output \> 0.5 ml/kg/h by infusing crystalloid solution and administering vasoactive drugs when considered necessary.
Sponsors
Peking University First Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age \> 18 years; 2. Planning to undergo partial nephrectomy;
Exclusion criteria
1. Patients with renal function damage (chronic kidney disease stage 3-5) before surgery; 2. Patients with arrhythmia or aortic valve diseases (moderate or higher degree stenosis/regurgitation); 3. Patients who has participated in other trials.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of acute kidney injury after surgery | During the first 3 days after surgery | Acute kidney injury is diagnosed according to KDIGO (Kidney Disease: Improving Global Outcomes) criteria |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Serum creatinine concentration | At 3 and 6 months after surgery | Serum creatinine concentration |
| Length of stay in hospital after surgery | From end of surgery to 30 days after surgery | Length of stay in hospital after surgery |
| Incidence of postoperative complications | From end of surgery to 30 days after surgery | Incidence of complications within 30 days after surgery |
Countries
China
Outcome results
None listed