Thyroidectomy
Conditions
Keywords
Laryngeal evoked brainstem response (LEBR), laryngopharyngeal sensory discrimination testing (LPSDT), brainstem activity
Brief summary
The primary purpose of this study will be to determine whether the proposed study protocol will allow for reliable detection of the human Laryngeal evoked brainstem responses (LEBR). Laryngeal evoked brain stem responses will be recorded from five test subjects under general anesthesia in the operating room with the assistance of an electrophysiologist with expertise in evoked potentials. Once the feasibility of obtaining tracings are established on the first few subjects, responses will be recorded from other test subjects with the aim of determining the optimal placement of stimulating electrodes and detection leads necessary to elicit an adequate response. The effect of varying the stimulus intensity will also be studied. Once parameters for testing have been standardized, normative configurations for the laryngeal evoked brainstem response tracings can be determined by patients both in the office setting and in the operating room.
Interventions
PROCEDUREPlacement of a needle electrode through the thyrohyoid membrane into the submucosal space within the false vocal fold
Sponsors
NYU Langone Health
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy Subjects undergoing thyroid or other open neck surgeries
Exclusion criteria
* Current or recent (within one month) tracheostomy * Vocal cord paralysis * History of Stroke * History of Diabetes Mellitus * History of Neurologic Disease * History of Radiation to the Neck * History of Brain Surgery * History of Neck Surgery * Recent Laryngeal Surgery (within one month) * Recent Intubation (within two weeks) * Laryngopharyngeal Reflux Disease * Allergy to Lidocaine * Allergy to Oxymetazoline
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| analysis of variance in brain auditory evoked response (BAER) measured using recording electroencephalography electrodes | One Year | Distributions of latencies within this group will be examined to evaluate the appropriateness of standard assumptions regarding normality and constant variance, and transformations or non-parametric statistics will be considered as needed. |
Countries
United States
Outcome results
None listed