Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using PRF

Regenerative Endodontic Procedure of Immature Permanent Teeth With Apical Periodontitis Using Platelet-rich Fibrin : A Pilot Randomized Controlled Trial

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02801552

Enrollment

Registered

2016-06-16

Start date

2016-05-31

Completion date

2020-02-29

Last updated

2021-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periapical Periodontitis, Stomatognathic Diseases, Tooth Diseases

Keywords

regenerative endodontic treatment, platelet-rich fibrin, Immature permanent tooth, apical periodontitis

Brief summary

This study evaluates the clinical effect of regenerative endodontic procedure using PRF in immature permanent teeth with apical periodontitis. Half of participants will receive the PRF instead of blood clots in the regenerative endodontic procedure, while the other half will receive a blood clots in the regenerative endodontic procedure.

Detailed description

The conventional method of regenerative endodontic procedure using a blood clot as scaffold materials has shown successful results. However, it is very difficult to induce bleeding and place mineral trioxide aggregate over a blood clot. Platelet-rich fibrin (PRF), a second-generation platelet concentrate. PRF is a matrix of autologous fibrin containing a large quantity of platelets, growth factors and leukocytes. PRF preparation technique is very simple, inexpensive and doesn't require any chemical agents. The purpose of this study is to test the hypothesis that the use of PRF in regenerative endodontic procedure of immature permanent teeth with apical periodontitis will accelerate periapical bone healing and stimulate the root maturation.

Interventions

DEVICEPRF

Regenerative Endodontic Procedure with PRF: autologous PRF will be used instead of blood clot in the second vist.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

6 Years to 18 Years

Healthy volunteers

Yes

Inclusion criteria

* Between 6 and 18 years of age * Provision of Informed Consent * Cooperative in the dental chair * Permanent immature teeth with apical periodontitis and incomplete root development

Exclusion criteria

* Have a medical history that may complicate treatment * Unlikely to be able to comply with the study procedures

Design outcomes

Primary

Measure	Time frame
Evidence of periapical healing	12 months

Secondary

Measure	Time frame	Description
Evidence of root development	24 months	—
Evidence of pulp sensibility	24 months	a positive response to pulp sensibility tests include cold test and electric pulp testing

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026