Cannabis Dependence
Conditions
Keywords
cannabis, fMRI, addiction, relapse
Brief summary
The aim of this fMRI study is to investigate neural indices of relapse in cannabis dependence. The development and maintenance of drug addictions have been associated with deficits in cognitive control, craving and impaired stress regulation. Therefore, neural markers of brain processes underlying the beforementioned components will be studied. Subsequent follow-up drug use interviews will reveal associations between relapse in cannabis dependence and alterations in brain networks of cognitive control, craving and stress.
Interventions
OTHERfMRI
Sponsors
German Research Foundation
University Hospital, Bonn
University of Electronic Science and Technology of China
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Cannabis Dependence * 24 hours abstinence
Exclusion criteria
* other DSM-4 diagnosis * neurological disorder
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI neural activation patterns of emotional processing | one time point = fMRI assessment after minimum 24 hours of abstinence | Activation patterns associated with emotion processing, emotion regulation, craving and stress are determined in addicted cannabis users compared to non-using matched control subjects |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Timeline Followback Interviews | one time point = 12 months after fMRI data acquisition | Association between fMRI correlates and drug use during follow up preiod as predictor for relapse |
Countries
Germany
Contacts
Primary ContactBenjamin Becker, PhD
Backup ContactKaeli Zimmermann, MSc
Outcome results
None listed