Amputation
Conditions
Keywords
allograft, hands, immunosuppression, fMRI
Brief summary
The double amputation of the forearms is a rare handicap that seriously impacts the autonomy and the quality of life of patients, social and familial exclusion, and dependence on third parties for everyday activities. The management of these patients is nearly exclusively through the use of prostheses. Certain patients refuse this solution, or remain penalized by the absence of sensation, the lack of precision in movements, and body image issues related to the amputation; the double graft of hands and forearms may, in this circumstance, be the only solution. The objective of this pilot study was designed to evaluate the cerebral plasticity of patients who undergo bilateral hand allograph
Interventions
PROCEDUREhand allograft
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
20 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* double amputated patients * minimum of 3 months and maximum of 3 years interval between amputation and graft * adult aged 20 to 40 years * psychological maturity * written informed consent
Exclusion criteria
* mono amputated patients * previous history of malignant tumor in remission for less than 5 years, * malignant tumor * previous psychiatric history * American Society of Anesthesiology (ASA) score \>2 * New York Heart Association (NYHA) \>1 * nenal insufficiency * severe hypertension
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| fMRI for evaluation of brain plasticity after transplant | 1 year | Evaluation of brain plasticity after transplant |
Secondary
| Measure | Time frame |
|---|---|
| Rejection | Every 6 months following graft up to 5 years |
| Adverse events | 5 years |
Countries
France
Outcome results
None listed