Pulmonary Arterial Hypertension
Conditions
Brief summary
Pulmonary hypertension is a rare and severe disease, affecting a young population. Survival is very poor and has been closely related to right ventricular dysfunction. Current prognostic equations rely mostly on right heart catheterization data. The identification of simple echocardiographic prognostic factor is urgently needed. It could help identifying with a non invasive method, high risk patients who could benefit from an intensive specific therapy. 3D right ventricular imaging is a new echocardiographic tool which provides RV volumic analysis, RV ejection fraction, overcoming the classical limits of 2D ultrasound. The aim of this study is to validate a new software for 3D analysis of the right ventricle and assess its prognostic role in pulmonary hypertension. To do so, the investigators will realize a prospective monocentric longitudinal cohort study, including 100 pulmonary hypertension patients. Echocardiographic data will be collected at baseline and after 6 months.
Interventions
DEVICE3D right ventricular imaging echocardiographic
Echocardiographic data (3D right ventricular imaging echocardiographic) will be collected at baseline and after 6months.
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients \> 18 years old * Pulmonary hypertension diagnosed by right heart catheterization * Informed consent obtained * Affiliation to the French national health insurance
Exclusion criteria
* Associated significant left heart disease * Sub-optimal acoustic windows * Patient unable to attend follow-up visits
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of death from any cause | Baseline to 24 months | Description of the number of death during the study |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of Hospitalisation | Baseline to 24 months | Description of the number of hospitalisation for worsening of pulmonary arterial hypertension |
| 3D right ventricular imaging echocardiographic | Baseline and 6 months | Analyse the data of 3D right ventricular (RV), ejection fraction, RV telediastolic and telesystolic volume, 3D RV area strain (%) |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORPAMELA MOCERI, MD
Centre Hospitalier Universitaire de Nice
Outcome results
None listed