Narcolepsy
Conditions
Keywords
narcolepsy, metabolism
Brief summary
A significant weight gain and obesity are observed for most patients with narcolepsy, mainly at the beginning of the disease and narcolepsy in young children. There is no specific study on the population and the consequences of overweight in the lives of these long-term patients. Narcoleptic patients gain weight significantly at the onset of their illness. It is also known that weight gain is not related to the treatment of narcolepsy. The etiology of obesity in narcoleptic patients is not established. Several assumptions were made (physical activity, leptin diet, metabolism). The reason and the pathophysiology of overweight and obesity in this population therefore remain unclear. In this study, potential change in the total metabolism (24h) for narcoleptic children that could explain their tendency to obesity will be assessed ?
Interventions
OTHERSleep and metabolism assessment
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
6 Years to 18 Years
Healthy volunteers
No
Inclusion criteria
NARCOLEPTIC PATIENTS * Girl or boy age\> 6 years \<18 years; * Narcoleptic: defined by the ICSD diagnostic criteria 2 (International Classification of Sleep Disorders) * Beginning of the troubles there more than 6 months * Parental consent and agreement of the child. HYPERSOMNIC PATIENTS * Girl or boy age\> 6 years \<18 years; * Hypersomnic : defined by the ICSD diagnostic criteria 2 (International Classification of Sleep Disorders) * Beginning of the troubles there more than 6 months * Parental consent and agreement of the child.
Exclusion criteria
NARCOLEPTIC PATIENTS * Secondary Narcolepsy; * Narcolepsy already treated with psychostimulant or anticataplectic; * Restless legs; * Sleep apnea syndrome; * Obesity known outside narcolepsy cause; * Absence of parental consent. HYPERSOMNIC PATIENTS * symptomatic or secondary hypersomnia; * Hypersomnia already treated psychostimulant or anticataplectic; Restless legs; * Sleep apnea syndrome; * Pathology neurological, psychiatric, endocrine or concurrent; * Lack of parental consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Determination of the metabolism at home | 15 days | Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at home (15 days including scholar and non-scholar days). |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Basal energy expenditure | 18 days | The basal metabolism (MET) measured by accelerometer (Actical, BodyMedia SW Actiheart) will be compared to the values of energy expenditure (kcal) measured by indirect calorimetry fasting. |
| Energy expenditure and diet-induced thermogenesis | 18 days | Energy expenditure (kcal) measured by indirect calorimetry after lunch (with counting calories ingested). |
| Sympathetic activity | 18 days | Estimated from IBI (Interbeat Interval) measured by Actiheart. |
| Food intake | 18 days | Caloric intake evaluation (kcal per day) during hospitalization (food intake recording) and at home during three days ( two days during the week and one day during the week-end) evaluated by questionnary. |
| Fasting peptide YY | 18 days | — |
| Body weight | 18 days | bodyweight (kg) |
| Body height | 18 days | Body height (cm) |
| Waist and hips circumference | 18 days | Waist and hips circumference (cm) |
| Measurement of neck | 18 days | Measurement of neck (cm) |
| Anthropometric measurements | 18 days | Measurement of BMI Z-score |
| Determination of the metabolism at hospital | 18 days | Total energy expenditure in kilocalories per minute, including basal metabolic rate (MET) metabolism related to the activity (EEA), and physical activity (PA) measured by accelerometer (Actical) evaluated at hospital over 24 hours. |
| Hunger | 18 days | hunger evaluation by visual analog scale before each meal |
| Fasting IL6-8 levels | 18 days | — |
| Fasting adiponectin | 18 days | — |
| Fasting resistin | 18 days | — |
| Fasting MCP1 | 18 days | — |
| Fasting PostPrandial | 18 days | — |
| Fasting GLP1 (glucagon-like peptide-1) | 18 days | — |
| Fasting Hba1C | 18 days | — |
| Body mass index z score | 18 days | — |
| sleep duration | 18 days | — |
| Appetite | 18 days | appetite evaluation by visual analog scale before each meal |
Countries
France
Outcome results
None listed