Cancer of the Digestive System, Thoracic Diseases
Conditions
Keywords
lymphopenia, postoperative infection, thoracic cancer surgery, digestive cancer surgery
Brief summary
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery.
Detailed description
Postoperative infections are one of the most common complications in thoracic and digestive cancer surgery. Former studies have demonstrated that inflammatory response is altered during peri-operative period causing lymphopenia. It has been suggested that lymphopenia may contribute to postoperative infection. To date, no one has proved it in a multivariate analysis. The aim of this study is to determine if lymphopenia is associated with postoperative infections in thoracic and digestive cancer surgery. It is a multicenter French cohort study. Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery before surgery (day-0) as well 1, 3, 5 and 8 days after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
Interventions
OTHERCollection of plasma cell rate
Lymphocytes counts are obtained from patients undergoing pulmonary or digestive cancer surgery. The rates are assessed before surgery (day 0) and at days 1, 3, 5 and 8 after surgery. Anesthetic and surgical procedures are collected as well as risk factors for postoperative infections recognized in the literature. Clinical and biological signs of infection are collected.
Sponsors
Centre Hospitalier Universitaire de Saint Etienne
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* patient undergoing digestive or thoracic cancer surgery under general anesthesia.
Exclusion criteria
* pregnant women, * malignant blood disease, * allograft patient, * preoperative sepsis or preoperative systemic inflammatory response syndrome.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Presence of post operative infection | 1 month | Patients undergoing general anesthesia for thoracic or digestive surgery could present lymphopenia. In this situation, the presence of post operative infection is notified. The correlation between lymphopenia and post operative infections is studied. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Anesthetic and surgical parameters | 1 month | To identify anesthetic and surgical parameters influencing postoperative lymphocytes cells count. |
Countries
France
Outcome results
None listed