Open Lung Approach Versus Standard Protective Strategies

Open Lung Approach Versus Standard Protective Strategies: Effects on Driving Pressure and Ventilatory Efficiency During Anesthesia

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02798133

Enrollment

Registered

2016-06-14

Start date

2014-07-31

Completion date

2014-11-30

Last updated

2017-04-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Lung Collapse

Brief summary

The aim of this study was to compare the effects of adding a recruitment maneuver (RM) to low tidal volume (VT) ventilation, with or without an individualized post-RM positive end-expiratory pressure (PEEP) setting in lung-healthy patients during anesthesia.

Interventions

PROCEDUREOLA

PEEP titration trial for best Cdyn after the alveolar recruitment maneuver

PROCEDURERM-5

Fixed standard PEEP after the alveolar recruitment maneuver

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* ASA physical status I-III undergoing elective major abdominal surgery including pancreatic-duodenectomy, gastrectomy and liver resection

Exclusion criteria

* i) laparoscopic surgery, ii) patients with previous respiratory disease.

Design outcomes

Primary

Measure	Time frame	Description
driving pressure	intraoperative	The driving pressure is a physiological ventilatory parameter measured as platteau pressure minus PEEP. This parameter may be associated with postoperative pulmonary complications

Secondary

Measure	Time frame	Description
ventilatory efficiency	intraoperative	Ventilatory efficiency measured with volumetric capnography which includes dead space and tidal elimination of carbon dioxide.

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 26, 2026