Cardiovascular Disease
Conditions
Keywords
Hyperuricemia, endothelial function, anthocyanidins
Brief summary
The purpose of this study is to confirm the protective effect and mechanism of anthocyanins on hyperuricemia patients with Cardiovascular disease.
Detailed description
Hyperuricemia patients who have the ability to complete the intervention study in the early stage of study were selected as the research subjects. A randomized controlled double blind control method was used to study the effect of one year of anthocyanins intervention. Serum UA levels, oxidative stress, AGEs, and endothelial function are detecting in patients with hyperuricemia who were treated with anthocyanins and placebo. Providing scientific basis of anthocyanins for the treatment with hyperuricemia and delaying atherosclerosis.
Interventions
DIETARY_SUPPLEMENTAnthocyanidins capsule
Continuous intervention for 1 years, detect the indicators in the intervention of 0,6,12 months
DIETARY_SUPPLEMENTPlacebo capsule
Continuous intervention for 1 years, detect the indicators in the intervention of 0,6,12 months
DRUGAllopurinol
Continuous intervention for 1 years, detect the indicators in the intervention of 0,6,12 months
Sponsors
Sun Yat-sen University
Guangzhou General Hospital of Guangzhou Military Command
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
30 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Serum uric acid \>420μmol/L (7mg/dL) in male, \>360μmol/L (6mg/dL) in female identified as hyperuricemia patients.
Exclusion criteria
* Age more than 60 years and less than 30 years old; * acute infection, tumor, recent surgery, need for hemodialysis and autoimmune diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of serum uric acid levels in all patients | up to 1 months | Serum uric acid (mg/dl) is determined by Uric Acid kit on an automated system. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Measurement of advanced glycation end products and its receptor level in all patients | up to 2 months | Advanced glycation end products and its receptor level are determined by high efficiency liquid chromatography. |
Countries
China
Contacts
Primary ContactHui Dai
Backup ContactYuan Zhang
Outcome results
None listed