Atherosclerosis, Cardiovascular Disease, Heart; Disease, Activity, Obesity
Conditions
Keywords
arterial stiffness, retinal vessels, physical activity, ageing
Brief summary
The aims of the study are twofold. In the cross-sectional approach (Part I), the study will be conducted in an older population to assess the association of physical fitness on different parts of the human vascular bed. In the interventional approach (Part II), it aims to investigate whether and to what extent advanced vascular ageing (AVA) in older subjects with increased cardiovascular risk can be reversed by regular walking- based high intensity interval training.
Detailed description
In the cross-sectional part the investigators analyze physical fitness, vascular health and further outcomes in a healthy older active, a healthy older sedentary and a obese sedentary group with increased cardiovascular risk. The investigators will analyze large and small artery function, physical fitness and activity as well as inflammatory parameters in these three groups. Here the investigators will investigate the influence of physical activity and inflammatory parameters on the vascular health in different beds. In the intervention part the older sedentary group with increasing cardiovascular risk (OSR) will be randomized in a control and an intervention group. The intervention group will get a high intensity interval training which is walking based and individual adjusted. The control group will get general lifestyle recommendations. After 12 weeks of training OSR group will be tasted again. The aim of the second part is to assess the effect of high intensity interval training on vascular health and inflammatory parameters.
Interventions
OTHERTraining or control condition
Participants get a 12 week high intensity and walking-based interval training which is adapted to their individual physical fitness level or a general recommendation on physical activity according to European Guidelines.
Sponsors
University Hospital, Basel, Switzerland
Basel Institute of Clinical Epidemiology (BICE)
University of Basel
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
50 Years to 79 Years
Healthy volunteers
Yes
Inclusion criteria
* men and women aged 50-79 years * Active lifestyle: \> 9 MET/week (\> 3hours moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2 * Sedentary lifestyle: ≤ 3 MET/week (≤ 1 hour moderate walking/week); 18.5≤ BMI ≤ 29.9 kg/m2 * Sedentary men and women aged 50-79 years with increased cardiovascular risk are allowed to have ≥ one additional cardiovascular risk factor
Exclusion criteria
* History of cardiovascular, pulmonary or chronic inflammatory disease * blood pressure ≥ 140/90 mmHg during 24h monitoring * current or past smoker (in healthy group) * macular degeneration or glaucoma * compromising orthopaedic problems
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of pulse wave velocity (m/s) | Change from baseline pulse wave velocity at 12 weeks | Measured at local, central and peripheral site |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change of augmentation index (AIx@75) in % | Change from baseline augmentation index at 12 weeks | AIx and AIx@75 will be measured by using the gold standard device for single measurements (SphygmoCor®) |
| Change of arteriolar to venular diameter ratio (AVR) in µm | Change from baseline AVR at 12 weeks | Dynamic and static retinal vessel analyzes will be investigated |
| Change of physical activity in METs per week | Change from baseline physical activity at 12 weeks | The Freiburger Questionnaire of physical activity and inactivity and an accelerometer for seven days will be used to measure physical activity. |
| Change of physical fitness in VO2max | Change from baseline VO2max at 12 weeks | An individual treadmill ramp test will be used to investigate peak oxygen consumption and maximal heart rate. |
Other
| Measure | Time frame | Description |
|---|---|---|
| Change of autonomic function in heart rate variability (HRV) in beats per minute (bpm) | Change from baseline HRV at 12 weeks | 12-lead ECG monitoring |
| Change of serum biomarkers (hs-CRP, IL-6, IL-10, TNF-α) | Change from baseline serum biomarkers at 12 weeks | Blood sampling |
| Change of cognitive Function | Change from baseline cognitive function at 12 weeks | Executive function test battery |
| Change of diastolic function parameters (E/A; E/E') | Change from baseline parameters at 12 weeks | Echocardiography |
Countries
Switzerland
Outcome results
None listed