Deep Brain Stimulation and Parkinson's Disease

Deep Brain Stimulation and Parkinson's Disease: Analysis of the Modifications of the Cortical Activation During Driving Tasks and During Tasks Involving the Control of the Impulses by Means of the Optical Imaging and of the Technique of Delay Discounting Task

Status

Completed

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02795663

Acronym

SCP TCI NIRS

Enrollment

Registered

2016-06-10

Start date

2014-09-01

Completion date

2017-12-31

Last updated

2025-09-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Parkinson Disease

Keywords

Near-InfraRed Spectroscopy (NIRS), Deep brain stimulation of SubThalamic Nucleus (DBS)

Brief summary

* Background : Deep brain stimulation of SubThalamic Nucleus (STN-DBS) is an effective treatment for a large variety of movement disorders. However, the efficacy of STN-DBS relies on unclear mechanisms. * Purpose: In this study, using optical imaging, the investigators will evaluate the cortical hemodynamic changes induced by STN-DBS of parkinsonian patients during motor task and delay discounting task. the investigators will perform an optical imaging study using Near-InfraRed Spectroscopy (NIRS) in a parkinsonian patient after STN-DBS. The investigators will measure bilateral local cortical hemodynamic changes under On and Off stimulation conditions and during a motor task (left hand movement) and delay discounting task Relative concentration changes of oxy-Hb, deoxy-Hb, and total Hb will be continuously analyze. * Primary outcome: Study of local cortical hemodynamic change (oxy-Hb, deoxy-Hb, and total Hb) under on and off stimulation during a motor task.

Interventions

DEVICENIRS EEG HR recording

NIRS EEG HR recording

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 75 Years

Healthy volunteers

Inclusion criteria

* Patients presenting Parkinson disease and treated by STN-DBS. * For comparison patients: Patients treated by DBS in other target.

Exclusion criteria

* Patients who cannot be treated by DBS

Design outcomes

Primary

Measure	Time frame	Description
Study of local cortical hemodynamic change (oxy-Hb, deoxy-Hb, and total Hb)	1 month,	under on and off stimulation during a motor task.

Secondary

Measure	Time frame	Description
Study of QUIP score (QUIP scale)	3 month	—
Comparison of local cortical hemodynamic changes (oxy-Hb, deoxy-Hb, and total Hb) with the localisation of the contact use for STN-DBS stimulation	1 month	between patient with ICD and patient without ICD
Study of local cortical hemodynamic change (oxy-Hb, deoxy-Hb, and total Hb)	1 month	under on and off stimulation during delay discounting task.
Study of local cortical hemodynamic changes (oxy-Hb, deoxy-Hb, and total Hb) with intensity of NonSTN-DBS stimulation	1 month	under on and off stimulation during a motor task and a delay discounting task (in order to obtain a qualitative comparison between GPi-DBS and STN-DBS.
Study of delayed discounting task (DDT) score	3 months	—
Comparison of local cortical hemodynamic changes (oxy-Hb, deoxy-Hb, and total Hb) with intensity of STN-DBS stimulation	1 month	—

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026