Ocular Penetration of Topical Tacrolimus
Conditions
Keywords
Tacrolimus, Ocular penetration, Topical
Brief summary
Investigators aim to evaluate the ocular penetration of topical tacrolimus 0.03% eye drops. Topical tacrolimus 0.03% will be instilled into the eyes of patients 15 minutes before cataract surgery. Aqueous samples will be collected at the time of cataract surgery and will be subjected to detection of presence and level of tacrolimus.
Interventions
DRUGTacrolimus
Topical tacrolimus 0.05% eye drops will be instilled into the eyes of patients every minute for 5 minutes. After 15 minutes, at the time of cataract surgery, aqueous samples will be collected and will be subjected to detection of presence and level of tacrolimus.
Sponsors
The Eye Center and The Eye Foundation for Research in Ophthalmology
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* Any age or gender * Patients scheduled for routine cataract surgery * Clear healthy cornea
Exclusion criteria
* Corneal pathology * Ocular surface disease * Intraocular inflammation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection of the concentration of tacrolimus ( nanograms/milliliter) in the anterior chamber following ocular topical application. | From date of obtaining the aqueous samples until getting the laboratory results of concentration of topical tacrolimus in the aqueous humor up to 2 months |
Countries
Saudi Arabia
Contacts
Primary ContactSsmir S Shoughy, MD
Outcome results
None listed