The Effect of Esmolol on Clinical Prognosis of Patients With Severe Sepsis

The Effect of Esmolol on Tissue Perfusion and Clinical Prognosis of Patients With Severe Sepsis: a Prospective Cohort Study .

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02794025

Enrollment

151

Registered

2016-06-08

Start date

2010-01-31

Completion date

2013-01-31

Last updated

2016-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Severe Sepsis

Brief summary

The purpose of this study was to investigate the effect of esmolol on hemodynamic parameters,tissue perfusion and the clinical prognosis of patients with severe sepsis

Detailed description

enrollment:151 patients Inclusion criteria: (1) age \> 18 years; (2) severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock, who (3) mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg; and (4) satisfactory sedation and analgesic treatment, with HR \> 100 bpm.

Interventions

DRUGEsmolol

patients in the esmolol group received continuous infusion of esmolol via a micro-pump through a catheter placed in the superior vena cava. The initial dose was 0.05 mg/kg/min and was adjusted based on heart rate (HR) (target HR: 70 bpm \< HR \< 100 bpm within 72 hours). Control group also received natural saline via a micro pump, in the same way the esmolol group received esmolol.

DRUGnatural saline

Control group also received natural saline via a micro pump,

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* age \> 18 years; * severe sepsis (acute organ dysfunction secondary to infection )diagnosis according to Campaign to Save Septic Patients: 2008 Treatment Guidelines for Severe Sepsis and Septic Shock, * mechanical ventilation via endotracheal intubation with a tidal volume of 6 mL/kg; * satisfactory sedation and analgesic treatment, with HR \> 100 bpm.

Exclusion criteria

* pre-existing cardiac dysfunction, valvular heart disease, high-degree atrioventricular block; * acute or chronic pulmonary heart disease; * a history of serious asthma; * chronic renal insufficiency; * cancer, autoimmune diseases, or contraindications for placement of deep venous catheter; * insulin-dependent diabetes.

Design outcomes

Primary

Measure	Time frame
The survival time of patients more than 28 days is defined as survival. The survival time of patients less than 28 days is defined as death.	28 days

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026