Periodontal Inflammation and Immunity in Preclinical Rheumatoid Arthritis

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02794012

Enrollment

146

Registered

2016-06-08

Start date

2016-07-31

Completion date

2017-12-31

Last updated

2018-01-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periodontal Disease, Rheumatoid Arthritis

Brief summary

The purpose of this study is to evaluate the association of Rheumatoid Arthritis (RA)-related antibodies and periodontal inflammation in subjects at-risk for Rheumatoid Arthritis. Subjects will undergo periodontal and joint examinations, as well as collection of body fluids to measure Rheumatoid Arthritis-related antibodies.

Interventions

None listed

Study design

Observational model

CASE_CONTROL

Time perspective

CROSS_SECTIONAL

Eligibility

Sex/Gender

ALL

Age

18 Years to 99 Years

Healthy volunteers

Yes

Inclusion criteria

* Rheumatoid Arthritis-antibody positivity (anti-CCP) in the absence of arthritis or * Early RA \<36 months since diagnosis

Exclusion criteria

* Pregnancy * Antibiotic use prior to dental procedures or cleanings * Wear dentures * \<18 years old

Design outcomes

Primary

Measure	Time frame
Degree of periodontal disease by oral examinations according to the American Academy of Periodontology (AAP) guidelines	1 day

Secondary

Measure	Time frame
Frequency of bacterial communities of the periodontium by bacterial diversity (e.g. Shannon Diversity Index) and bacterial load (qPCR)	1 day
Frequency of Rheumatoid Arthritis-related antibodies in blood and mucosal sites using Rheumatoid Factor and Anti-Citrullinated Protein Antibody assays	1 day

Countries

United States

Outcome results