Anesthesia, Local Anesthesia
Conditions
Brief summary
With blocks of lumbar and lumbar plexus, we can reduce the intravenous anesthetics usage. To offer an satisfied surgery process for patients, a proper sedation is necessary. So in this study, we want to investigate the influence of two different sedative drugs on outcomes of patients received hip replacement surgery .
Interventions
DRUGpropofol
For patients in Group P, the sedation was achieved with a target-controlled infusion (TCI) of propofol, and the effect site concentration was set to 0.8-1.0μg/ml.
DRUGdexmedetomidine
For patients in Group D, the sedation was achieved with a bolus of dexmedetomidine at 1.0 μg/kg (over a period of 15 to 20 min) and followed by an infusion of dexmedetomidine at 0.2-0.7 μg/kg/h. The depth of sedation was considered enough when patient was unresponsive to voice.
Sponsors
The First Affiliated Hospital of Anhui Medical University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
TRIPLE (Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
65 Years to 85 Years
Healthy volunteers
No
Inclusion criteria
* 65 years or older and undergoing hip fracture repair
Exclusion criteria
* Patients with severe cognitive impairment (MMSE score, \<15) * Preoperative delirium as determined by Confusion Assessment Method * Contraindications to local anesthesia * Prior hip surgery * Mental or language barriers that would preclude data collection * Severe congestive heart failure (NewYork Heart Association class IV) * Severe chronic obstructive pulmonary disease (Global Initiative for Chronic Obstructive Lung Disease guidelines, stage III-IV)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium | 7 days after surgery |
| Mortality in 30 days after surgery | 30 days after surgery |
Secondary
| Measure | Time frame |
|---|---|
| Out of bed time | 7 days after surgery |
| Discharge time | 30 days after surgery |
| Complications of cardiopulmonary system | 30 days after surgery |
| Extubation time | 7 days after surgery |
| Hemodynamic index | intraoperative |
| Dosage of vasoactive agent | During sugary |
| Incidence of cerebrovascular accident | 30 days after surgery |
Countries
China
Outcome results
None listed