Optic Disc Drusen
Conditions
Keywords
Drusen, SD-OCT
Brief summary
Optic nerve head Drusen are a mostly bilateral change of the optic nerve, eventually causing a slow, but progression loss of the visual fields. Characteristic are the crystalline deposits at the entrance of the optic nerve, the so called optic disc. The material consists of calcium, calcium phosphate, iron, but also amino acids and polysaccharides. The diagnose is made or confirmed by different imaging modalities like ultrasound and auto-fluorescence imaging. By using the high-resolution imaging with spectral-domain optical coherence imaging (SD-OCT) the volume and deposits at the optic disc can be measured and quantified. The purpose of this study whether and how defects in the visual fields are related to the deposits. Multimodal imaging of the optic nerve head is planned within the cross-sectional study, at two different time intervals (2 years). Changes in retinal fibre layer (RNFL) thickness and disc parameters are analyzed. Presence and extent of auto-fluorescent changes are evaluated. The prospective trial wants to clarify whether certain parameters at baseline indicate the further outcome and development.
Interventions
DEVICEImaging
Sponsors
University Hospital Tuebingen
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Healthy volunteers
No
Inclusion criteria
* patients with Drusen of the optic disc (as proven by ultrasound and clinical appearance)
Exclusion criteria
* mental disability * loss of fixation * other eye diseases potentially leading to a loss of visual fields
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in RNFL thickness | baseline and 2 years |
Secondary
| Measure | Time frame |
|---|---|
| Loss of Visual Fields | baseline and 2 years |
| Change in auto-fluorescent areas | baseline and 2 years |
| Change in Drusen material | baseline and 2 years |
Countries
Germany
Outcome results
None listed