Risk of Ectopic Pregnancy and Variation of Luteal Estradiol and Progesterone Levels in IVF

Retrospective Cohort Study of Increased Risk of Ectopic Pregnancy Associated With Marked Variation of Estradiol During the Early Luteal Phase and High Progesterone on hCG Day in IVF

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02793089

Enrollment

578

Registered

2016-06-08

Start date

2005-01-31

Completion date

2016-05-31

Last updated

2016-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ectopic Pregnancy

Brief summary

This study evaluates the increased risk of ectopic pregnancy associated with marked variation of estradiol during the early luteal phase and high progesterone on hCG day in IVF.

Detailed description

This is a retrospective cohort study of 578 patients who had no risk of EP (672 fresh transfer IVF cycles) between January 2005 and December 2014. Few studies have reported the relation between hormonal levels and ectopic pregnancy (EP) in IVF. Investigators describe EP incidence according to estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7) or their variation between both days.

Interventions

OTHERAnalysis of Ectopic Pregnancy incidence

Collect retrospectively data. Analysis of Ectopic Pregnancy incidence through Estradiol (E2) and progesterone (P4) levels on hCG day and seven days later (hCG+7)

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

25 Years to 45 Years

Healthy volunteers

Inclusion criteria

* Normal Fallopian tubes in HSG and /or laparoscopy * Normal Uterus: Abscence of myomas and Müllerian anomalies .

Exclusion criteria

* Previous Ectopic Pregnancy . * Recurrent Abortion . * Tubal Factor : pelvic inflammatory disease, Hydrosalpinx * Previous abdominal surgery (except laparoscopy) . * Prior Peritonitis * Smoking (at least 1 cigarette/day) .

Design outcomes

Primary

Measure	Time frame
Ectopic pregnancy rate	Up to 108 months

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026