Oxidative Stress
Conditions
Keywords
Depth of anesthesia, BIS, ERCP, Positive Regulation
Brief summary
Objective Endoscopic Retrograde Cholangiopancreatography (ERCP) is performed for resolving cholestasis by sphincterotomy and/or stone extraction and is done with deep sedation or general anesthesia. The investigators primary outcome was to evaluate the effects of the depth of anesthesia on oxidative stres provided via Bispectral Index (BIS) monitorisation during the ERCP procedure by analyzing the biochemical parameters. And their secondary outcome was the effects of anesthesia depth on propofol consumption and postoperative sedation status.
Detailed description
50 patients undergoing ERCP procedure were randomly allocated in two groups. Propofol was given to provide the patients Ramsey sedation scale as 3 and 4 in Group R (n=25) patients whereas it was given to Group B (n=25) patients to provide BIS values between 65 to 85. The levels of total oxidant status (TOS), total antioxidant status (TAS), and Oxidative stres index (OSI) were measured. Hemodynamic signs, propofol consumption, postoperative recovery time were recorded.
Interventions
DEVICEBispectral Index Monitorisation (BIS)
Standard monitoring was performed with electrocardiography, pulse oximetry and non invasive blood pressure. Additionally, Bispectral index (Aspect Medical Systems, Natica, MA) electrodes were connected to Group B patients
Propofol administration was done to keep the Ramsey Sedation scale of 3 or 4
Sponsors
Antalya Training and Research Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients with American Society of Anesthesiologists physical status I-II * Patients undergoing ERCP procedures
Exclusion criteria
* uncontrolled comorbidities (hypertension, diabetes mellitus, kidney-liver failure) * difficulty in communication (language problems, such as deafness) * who are allergic to the drugs used * pregnant women
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effects of BIS on oxidative stress | one day | The investigators aimed to investigate the effects of anesthesia with monitoring the depth of anesthesia using BIS on oxidative stres by measuring the total oxidant status (TAS) and total antioxidant status (TOS) , propofol consumption, and postoperative recovery during ERCP procedures in this study. |
Outcome results
None listed