Neuroscience of Dreaming, Healthy
Conditions
Keywords
Psychology, Dreams
Brief summary
In this study, the investigators pose the question which influence the opioid circuit has on positive valent situations in dreams.
Interventions
DRUGNaltrexone
one week
OTHERPlacebo
one week
Sponsors
Insel Gruppe AG, University Hospital Bern
University of Bern
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
MALE
Age
20 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* Written informed consent * Healthiness * Good capacity of remembering dreams * No opiate consumption
Exclusion criteria
* Simultaneous participation in other studies * Addictive disorder * Abnormal liver function * Abnormal kidney function * Hypersensitivity to active ingredient or pharmaceutical additives * Hereditary galactose intolerance * Lactase deficiency * Glucose-galactose malabsorption * Intake of opioid medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| VAS-difference concerning the emotional valence of dreams | 7 days per condition (Naltrexone, Placebo), intermitted by 14 days of washout | Difference between the mean values of emotional valence of dreams reported in the conditions (Naltrexone, Placebo), as captured in VAS \[visual analog scales\] for every dream |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Semiquantitative score of emotional valence of dreams | 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout | Based on computational linguistic analysis of the dreams |
| Qualitative score of emotional valence of dreams | 7 days per condition (Baseline, Naltrexone, Placebo), intermitted by 14 days of washout | Based on lexical coding of the dreams |
Countries
Switzerland
Outcome results
None listed