Healthy Volunteers
Conditions
Keywords
T1rho MRI, hip, cartilage, Healthy participants
Brief summary
Hip osteoarthritis is a frequent and invalidating disease. Early detection of cartilage modifications could provide better patient treatment. The T1rho MRI sequence allows the quantification of the cartilage signal that is correlated to modifications of the cartilage matrix, notably of the proteoglycans. The primary objective is to evaluate normal values of hip cartilage in vivo using T1rho MRI in healthy subjects and the reproducibility of the measurements. T1rho and T2 mapping sequences were acquired twice during the same session with 30 minutes interval to see if values were modified after a 30 minutes delay in a supine position. The secondary objective was to assess the correlation between T1rho and T2 values.
Interventions
DEVICEHip cartilage MRI
Hip cartilage MRI
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* BMI \<30 * Accepting to participate in the study and signed the written informed consent * Covered by a health insurance system
Exclusion criteria
* Pregnant woman or risk of pregnancy * MRI contraindication * Protected adults * Language barrier * Previous or current hip pain
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Quantification of the cartilage signal at T1rho MRI | Up to one month after inclusion (Visit 1) | T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Quantification of the cartilage signal at T1rho MRI | 15 (+/- 7) days after visit 1 (Visit 2) | T1rho values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) |
| Quantification of the cartilage signal at T2 MRI | Up to one month after inclusion (Visit 1) | T2 values of total hip cartilage and for each sub-region (mean, standard deviation, histogram) |
| Presence of cartilage lesions | Up to one month after inclusion (Visit 1) | Morphological sequence to determine focal lesions |
Countries
France
Contacts
PRINCIPAL_INVESTIGATORJean-Baptiste PIALAT, MD, PhD
Hospices Civils de Lyon
Outcome results
None listed