Migraine Disorders, Brain
Conditions
Keywords
Audition, Stroke, Migraine, Attention, Short-term memory,, Emotions, EEG, MEG
Brief summary
The project studies auditory processing after brain damage (in temporal and/or frontal areas) and in migraine. The auditory processes investigated are attention, short-term memory, sound-induced emotions. To characterize auditory deficits after brain damage or in migraine, neuropsychological assessments are combined with neurophysiological markers (Electro-encephalography: EEG, Magneto-encephalography: MEG, Magnetic Resonance Imaging: MRI).
Interventions
OTHERNeuropsychological tests
Neuropsychological tests consist in listening to sounds in various contexts and providing behavioral responses with response-buttons.
OTHERNeurophysiological tests
Neurophysiological tests consist in the recording of EEG and/or MEG signals while realizing the neuropsychological tests, as well as MRI scanning to characterize the patients' brain lesions and reconstruct the brain sources of surface EEG/MEG signals.
Sponsors
Hospices Civils de Lyon
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Age from 18 to 80 * MEG/MRI compatibility * Motivation to participate efficiently in the study * No severe hearing loss * Informed consent to participate in the study * Affiliation to social security * For brain-damaged patients : no need for medical assistance; focal temporal and/or frontal lesion; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; testing at least one-month after the event resulting in brain damage; absence of neurological and psychiatric disorders besides the lesion * For migraine patients: no need for medical assistance; migraine diagnosis; no major cognitive impairment; ability to understand and apply the instructions for neuropsychological testing; absence of neurological and psychiatric disorders besides the migraine * Healthy participants: absence of neurological and psychiatric disorders
Exclusion criteria
* Age below 18 or above 80 * MRI scanning not possible: artificial cardiac pacemaker, insulin pump, metallic prosthesis, intra-cerebral clip, claustrophobia * MEG acquisition not possible: large heads, neurostimulator, metal in the head or the body. * Pregnant or breast-feeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Percentages of correct responses in Neuropsychological tests | up to 2 months |
| reaction times in Neuropsychological tests | up to 2 months |
Secondary
| Measure | Time frame |
|---|---|
| Event-Related Potentials (EEG) in Neurophysiological tests | up to 2 months |
| Event-Related Fields (MEG) in Neurophysiological tests | up to 2 months |
Countries
France
Outcome results
None listed