Respiratory Variability in Aortic Blood Velocity Measured by Suprasternal View as an Indicator of Fluid Responsiveness

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02791984

Acronym

SUPRA-PAM

Enrollment

Registered

2016-06-07

Start date

2015-04-30

Completion date

2016-03-31

Last updated

2016-06-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiovascular System

Keywords

Suprasternal, echography, fluid responsiveness

Brief summary

Respiratory changes in aortic blood velocity have been described as an indicator of fluid responsiveness when measured in the left ventricular outflow tract by trans esophageal echography. A threshold value of 12% allowed discrimination between responders and nonresponders with a sensitivity of 100% and a specificity of 89%. The suprasternal window is already used to measure cardiac output. The primary endpoint of this study is to determine the predictive value of the respiratory variability in aortic blood velocity measured by suprasternal view (∆VpicSS) as an indicator of fluid responsiveness. The secondary endpoint is to compare maximum velocity and velocity time integral measured by suprasternal and transthoracic view.

Interventions

DEVICEFluid challenge with 250 ml of Ringer Lactate

Fluid challenge with 250 ml of Ringer Lactate over less than 2 minutes, intra-venous, help by a syringe of 50 ml. Measure of peak velocity before and after the fluid challenge

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Age more than 18 years * American Society of Anesthesiologists (ASA) score 1 or 2 * General Anesthesia with mechanical ventilation * General Surgery

Exclusion criteria

* Arrhythmia * Spontaneous breathing activity * Significant valvular disease

Design outcomes

Primary

Measure	Time frame	Description
Percentage of cardiac flow variability	At day 1(before surgery)	Percentage of cardiac flow variability between the 2 echographic measures. Echographic measures will be realized a first time before fluid challenge by suprasternal view and a second time after the fluid challenge by suprasternal view.

Secondary

Measure	Time frame	Description
Comparison of percentage of cardiac flow variability between transthoracic and suprasternal views	At day 1(before surgery)	Echographic measures will be realized a first time before fluid challenge by transthoracic and by suprasternal view and a second time after the fluid challenge by transthoracic and by suprasternal view.

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026