STEMI
Conditions
Brief summary
The overall objective of this research proposal is to use OCT to investigate those morphological culprit plaque characteristics associated with the risk of developing MVO in reperfused STEMI patients.
Detailed description
The specific research objectives include: 1. To use OCT to determine the type of plaque (plaque rupture, plaque erosion or calcified nodule) most associated with the presence and severity of MVO (as measured by IMR and cardiac MRI). 2. To use OCT to investigate the relationship between the extent of tissue protrusion and the amount of residual stent thrombus with the presence and severity of MVO (as measured by IMR and cardiac MRI).
Interventions
PROCEDUREOptical coherence tomography (OCT)
Special camera to study part of your heart that was affected
PROCEDUREIndex of microcirculatory resistance (IMR)
Special wire to study part of your heart that was affected
OTHERCardiac MRI
Special scanner if the heart to assess the damage of your heart
Sponsors
National Heart Centre Singapore
Study design
Observational model
CASE_ONLY
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
21 Years to 99 Years
Healthy volunteers
No
Inclusion criteria
1. Confirmed STEMI as per the in-charge consultant based on presenting history, ECG and angiogram findings. 2. \< 12 hours of onset of chest pain. 3. Ability to provide informed consent
Exclusion criteria
1. Previous myocardial infarction or coronary artery bypass graft surgery 2. Cardiac arrest or cardiogenic shock 3. Inability to advance the OCT catheter or to obtain good image quality 4. Ostial lesions 5. Significant renal impairment 6. Contraindications for cardiac MRI 7. Contraindication for adenosine (for IMR measurement)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| All cause mortality | Two years |
Countries
Singapore
Contacts
Primary ContactMung Peng
Backup ContactDerek Hausenloy
Outcome results
None listed