Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People

SingHEART: Effects of Physical Activity, Ambulatory Blood Pressure and Calcium Score on Cardiovascular Health in Normal People

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT02791152

Acronym

SingHEART

Enrollment

1000

Registered

2016-06-06

Start date

2015-10-31

Completion date

2036-12-31

Last updated

2016-06-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial Infarction

Brief summary

A prospective cohort of relatively healthy individuals, using comprehensive clinical information, advanced imaging (including cardiac MRI), cardiovascular exercise physiology, metabolomics and genetic analysis. These findings will be correlated with adverse clinical outcomes including death, stroke and myocardial infarction. In selected cases, follow-up imaging and biomarker samples will also be obtained. These studies will enable us to begin to address a critical gap in our knowledge as to how best to interpret the very large amount of cardiovascular tests done in Singapore and how to better to predict outcomes and manage healthcare costs in our local populations

Detailed description

SingHEART sub-study will collect the following data types or perform the following investigations: 1. Demographic and clinical characteristics data. 2. Basic blood investigations. Basic blood investigations include: FBC, CRP, renal panel, random glucose, LFT, fasting lipids, ESR, CRP, 3. Perform a single baseline cardiac MRI (already consented and obtained as part of the primary study). 4. ECG 5. Calcium score 6. Biobanking (whole blood, plasma and serum, already performed as part of the primary study) 7. Exercise and physical activity tracker over two 1-week periods 8. Ambulatory BP monitoring over two 24-48H periods

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

21 Years to 69 Years

Healthy volunteers

Yes

Inclusion criteria

* Men and women age 21-69 years

Exclusion criteria

1. Previous myocardial infarction (MI). This will include ST-elevation MI (STEMI) and non-ST-elevation MI (NSTEMI) 2. Known coronary artery disease - prior coronary revascularization 3. Known documented peripheral arterial disease 4. Previous stroke a. Stroke is defined as new focal neurological deficit persisting more than 24hours21. 5. More than ongoing use of 2 or more anti-hypertensive agents 6. Prior history of cancer (excludes pre-cancerous lesions) 7. Expected life expectancy less than 1 year 8. Known definite diabetes mellitus or on treatment for diabetes mellitus 9. Known autoimmune disease or genetic disease 10. Known endocrine disease on treatment 11. Psychiatric illness 12. Asthma or chronic lung disease requiring long term medications or oxygen 13. Chronic infective disease, including tuberculosis, hepatitis B and C; and HIV 14. Inability to comply with study protocol 15. Any other acute or chronic medical or physical condition deemed by the investigator to affect study outcomes

Design outcomes

Primary

Measure	Time frame
First cardiovascular event	1 year

Countries

Singapore

Contacts

Primary ContactYeo Khung Keong, MBBS

67048963

Backup ContactYuen Yet Lee, Nursing

67042295

Outcome results