Angina Pectoris, Variant, Statins, HMG-CoA
Conditions
Keywords
statin, vasospastic angina
Brief summary
The purpose of this study is to evaluate whether statin is effective in the treatment of vasospastic angina.
Interventions
DRUGAtorvastatin
20mg QD
DRUGPlacebo
Placebo drug will be administered.
Sponsors
CardioVascular Research Foundation, Korea
Seung-Jung Park
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Age 19 and more * Vasospastic angina * LDL less than 160mg/dl * Written consent
Exclusion criteria
* Coronary artery stenosis more than 50% or ischemic coronary disease * History of percutaneous coronary intervention * Cerebrovascular diseases or peripheral * Dyslipidemia required statin therapy * Heart failure, arrhythmogenic right ventricular dysplasia, hypertrophic cardiomyopathy, akinesia or aneurysm on left ventricular wall, anomaly of coronary artery * NYHA III and IV * Arrhythmia * Primary cardiac electrical diseases * Cardiac pacemaker or implantable defibrillator * Pregnancy or breast feeding * Life expectancy less than 2 years
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The Composite Event of all-cause death, myocardial infarction, angina-related hospitalization | 3 years | The number of events with the first occurrence of a composite event(all-cause death, myocardial infarction, angina-related hospitalization) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| cardiac death | 3 years | — |
| cardiac arrest | 3 years | — |
| myocardial infarction | 3 years | — |
| all-cause death | 3 years | — |
| Composite event of death or myocardial infarction | 3 years | — |
| Composite event of cardiac death or myocardial infarction | 3 years | — |
| statin-related complications | 3 years | event rate of statin-related complications |
| angina-related hospitalization | 3 years | — |
Countries
South Korea
Outcome results
None listed