Relationship Between Left Ventricular Remodeling, Coronary Endothelial Function and Myocardial Fibrosis Using Positron Emission Tomography in Patients With ST-elevation Myocardial Infarction

Assessment of Coronary Endothelial Function and Myocardial Fibrosis in Positron Emission Tomography With the Waning of Acute Coronary Syndrome With Elevated ST Segment : Relationship With Left Ventricular Remodeling

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT02789098

Acronym

REMOD-TEP

Enrollment

Registered

2016-06-02

Start date

2016-10-13

Completion date

2025-09-30

Last updated

2026-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ST Elevation Myocardial Infarction

Keywords

ST Elevation Myocardial Infarction, Ventricular remodeling, Biomarkers, Coronary endothelial function, Positron Emission Tomography

Brief summary

Left ventricular remodeling is a common complication in patients with ST-elevation myocardial infarction (STEMI ) and may lead to heart failure. Hemodynamic, metabolic and inflammatory mechanisms are involved in this pathophysiological process. Recent data demonstrated that remote, noninfarct-related region of the myocardium is also implicated. There is no data about the assessment of coronary endothelial function or myocardial fibrosis in the remote zone in patients with STEMI . The correlation between these parameters and left ventricular remodeling is not known.

Interventions

OTHER(15)-O water positron emission tomography and Biomarkers

Coronary endothelial function is assessed using (15)-O water positron emission tomography and cold pressor test . The response to the test is defined by the percentage increase myocardial blood flow . Assessment of fibrosis, inflammation an endothelial function is performed using biomarkers.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

OTHER

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* First ST Elevation Myocardial Infarction * Primary Percutaneous Coronary Intervention (TIMI 3) * Single vessel coronary artery disease * Age over 18 years * Informed Consent dated and signed * Written and spoken French * Beneficiary of social security insurance

Exclusion criteria

* No Primary Percutaneous Coronary Intervention * TIMI 0-2 after Primary Percutaneous Coronary Intervention * Significant two or three-vessel coronary artery disease (\> 70% stenosis in at least one of the other two coronary arteries) * Past history of myocardial infarction before STEMI * Mechanical complication (ischaemic mitral regurgitation, interventricular septal defect, cardiac tamponade) or clinical signs of heart failure * Pregnant and / or lactating * Age under 18 years or guardianship

Design outcomes

Primary

Measure	Time frame	Description
Measurement of coronary endothelial function	3 months	3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .
Measurement of fibrosis	3 months	3 months following an acute coronary syndrome STEMI an ST segment (segments in myocardial infarcted area and "remote" ) .

Secondary

Measure	Time frame
Correlating biomarkers with local and global parameters of coronary endothelial function , inflammation and myocardial fibrosis with early echocardiographic parameters of left ventricular remodeling and cardiac magnetic resonance imaging	3 months

Countries

France

Contacts

STUDY_CHAIRFarzin GF BEYGUI, PhD

University Hospital, Caen

STUDY_CHAIRAlain MA Manrique, PhD