Muscle Relaxation Caused by Sevoflurane
Conditions
Keywords
sevoflurane, rocuronium, intubation
Brief summary
This study evaluates the potentiation of muscle relaxation caused by rocuronium by inhalational agent sevoflurane. Half the patients will be ventilated with oxygen ,nitrous oxide and sevoflurane during induction of anaesthesia and half will be ventilated only with oxygen and nitrous oxide.
Detailed description
Rocuronium is a non depolarizing muscle relaxant. Inhalational general anaesthetic agents like Sevoflurane have some muscle relaxation effect by depressing the spinal motor neurons. Inhalational anaesthetics also alter the tonic input received from descending modulatory systems from the brain. Deep anaesthesia with inhalational agents may cause some degree of neuromuscular blockade.
Interventions
DRUGSevoflurane
Patients were ventilated with 2 % inspired concentration of sevoflurane in a fresh gas flow of 5 litres containing 66.6% nitrous oxide and 33.3% percent of oxygen
DRUGRocuronium
rocuronium 0.6mg per kg body weight was given intravenously after induction of anaesthesia
Sponsors
Jaslok Hospital and Research Centre
Maharashtra University of Health Sciences
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* American society of anaesthesiologists physical status 1 and 2 * Age between 18-65 * Mallampatti classification 1 and 2
Exclusion criteria
* Patients refusal to participate * American society of anaesthesiologists physical status 3 and 4 * Mallampatti classification 3 and 4 * Patients with neuromuscular disorder * Patients on medications that affect neuromuscular block * Pregnant and lactating patients
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| intubating condition | 10 minutes | Copenhagen Consensus Conference Scale-scale to assess ease of intubation consisting of 5 parameters.laryngoscopy,vocal cord movement,vocal cord position,movement at intubation,coughing at intubation all are judged as poor ,good or excellent.If any parameter has a poor score, it is a clinically unacceptable intubating condition. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| lag time | 10 minutes | time from start of rocuronium injection to first change in single twitch height on neuromuscular monitor |
| onset time for maximum relaxation | 10 minutes | time from start of rocuronium injection to the disappearance of all four twitches on train of four stimulus on neuromuscular monitor |
Countries
India
Outcome results
None listed